InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LZTS1

Summary

InnateDB Protein

IDBP-474472.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LZTS1

Protein Name

leucine zipper, putative tumor suppressor 1

Synonyms

F37; FEZ1;

Species

Homo sapiens

Ensembl Protein

ENSP00000429263

InnateDB Gene

IDBG-9778 (LZTS1)

Protein Structure

UniProt Annotation

Function

Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor. {ECO:0000269PubMed:10097140, ECO:0000269PubMed:11464283, ECO:0000269PubMed:11504921}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Note=Associated with the plasma membrane and with microtubules. Detected in dendritic spines, especially in the postsynaptic density (By similarity). {ECO:0000250}.

Disease Associations

Esophageal cancer (ESCR) [MIM:133239]: A malignancy of the esophagus. The most common types are esophageal squamous cell carcinoma and adenocarcinoma. Cancer of the esophagus remains a devastating disease because it is usually not detected until it has progressed to an advanced incurable stage. {ECO:0000269PubMed:10097140}. Note=The disease may be caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Highly expressed in testis, prostate, spleen, thymus, ovary and brain. Detected at lower levels in heart, placenta, small intestine, colon, liver, kidney, skeletal muscle and pancreas. Not detectable in primary tumors from breast and prostate and in many cancer cell lines. {ECO:0000269PubMed:10097140}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006383	transcription from RNA polymerase III promoter
GO:0006385	transcription elongation from RNA polymerase III promoter
GO:0006386	termination of RNA polymerase III transcription
GO:0007049	cell cycle
GO:0010467	gene expression
GO:0016242	negative regulation of macroautophagy
GO:0032481	positive regulation of type I interferon production
GO:0045087	innate immune response