Version 5.4
Homo sapiens Protein: ZFAT
Summary
InnateDB Protein IDBP-474493.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZFAT
Protein Name zinc finger and AT hook domain containing
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000427831
InnateDB Gene IDBG-36602 (ZFAT)
Protein Structure
UniProt Annotation
Function May be involved in transcriptional regulation. Overexpression causes down-regulation of a number of genes involved in the immune response. Some genes are also up-regulated (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}.
Disease Associations
Tissue Specificity Isoform 1 is strongly expressed in placenta, spleen, kidney, testis and peripheral blood leukocytes. Expressed in CD4+ and CD8+ T-cells, CD19+ B-cells and CB14+ monocytes. Isoform 3 is strongly expressed in placenta, ovary, tonsil, CD19+ B-cells and CD14+ monocytes. {ECO:0000269PubMed:15294872}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR007087 Zinc finger, C2H2
IPR015880 Zinc finger, C2H2-like
PFAM PF00096
PRINTS
PIRSF
SMART SM00355
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9P243
PhosphoSite PhosphoSite-Q9P243
TrEMBL
UniProt Splice Variant
Entrez Gene 57623
UniGene Hs.446172
RefSeq NP_001276323
HUGO HGNC:19899
OMIM 610931
CCDS CCDS43768
HPRD 11712
IMGT
EMBL AB040918 AB167738 AB167739 AB167740 AB167741 AC015599 AC087045 AC135075 BC025423 BC046180 BC101766 BC101768 BC143519
GenPept AAH25423 AAH46180 AAI01767 AAI01769 AAI43520 BAA96009 BAD12567 BAD12568 BAD12569 BAD12570

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca