Version 5.4
Homo sapiens Protein: NCOA2
Summary
InnateDB Protein IDBP-474909.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NCOA2
Protein Name nuclear receptor coactivator 2
Synonyms bHLHe75; GRIP1; KAT13C; NCoA-2; SRC2; TIF2;
Species Homo sapiens
Ensembl Protein ENSP00000430148
InnateDB Gene IDBG-24827 (NCOA2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 88 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
Experimentally validated
Total 88 [view]
Protein-Protein 78 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 6 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 20 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0004402 histone acetyltransferase activity
GO:0004871 signal transducer activity
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity
GO:0046983 protein dimerization activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007165 signal transduction
GO:0016573 histone acetylation
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR000014 PAS domain
IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
IPR013767 PAS fold
IPR014935 Steroid receptor coactivator
PFAM PF13188
PF13426
PF00010
PF00989
PF08832
PRINTS
PIRSF
SMART SM00091
SM00353
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL E7EWM1
UniProt Splice Variant
Entrez Gene 10499
UniGene Hs.727231
RefSeq XP_005251190
HUGO HGNC:7669
OMIM 601993
CCDS
HPRD 09066
IMGT
EMBL AC021558 AC022730 AC084251 AC090731
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca