InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KLKB1

Summary

InnateDB Protein

IDBP-47496.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KLKB1

Protein Name

kallikrein B, plasma (Fletcher factor) 1

Synonyms

KLK3; PPK;

Species

Homo sapiens

Ensembl Protein

ENSP00000264690

InnateDB Gene

IDBG-47494 (KLKB1)

Protein Structure

UniProt Annotation

Function

The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.

Subcellular Localization

Secreted.

Disease Associations

Prekallikrein deficiency (PKK deficiency) [MIM:612423]: This disorder is a blood coagulation defect. {ECO:0000269PubMed:14652634, ECO:0000269PubMed:17598838}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0005515	protein binding

Biological Process

GO:0002542	Factor XII activation
GO:0006508	proteolysis
GO:0007596	blood coagulation
GO:0007597	blood coagulation, intrinsic pathway
GO:0022617	extracellular matrix disassembly
GO:0030198	extracellular matrix organization
GO:0031638	zymogen activation
GO:0031639	plasminogen activation
GO:0042730	fibrinolysis
GO:0051919	positive regulation of fibrinolysis

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000177 Apple domain
IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR003014 PAN-1 domain
IPR003609 Apple-like
IPR009003 Trypsin-like cysteine/serine peptidase domain

PFAM

PF00089
PF00024

PRINTS

PR00005
PR00722

PIRSF

SMART

SM00223
SM00020
SM00473

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt