Homo sapiens Gene: KLKB1 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-47494.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | KLKB1 | ||||||||||||||||||||||
Gene Name | kallikrein B, plasma (Fletcher factor) 1 | ||||||||||||||||||||||
Synonyms | KLK3; PPK | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Gene | ENSG00000164344 | ||||||||||||||||||||||
Encoded Proteins |
kallikrein B, plasma (Fletcher factor) 1
kallikrein B, plasma (Fletcher factor) 1
kallikrein B, plasma (Fletcher factor) 1
kallikrein B, plasma (Fletcher factor) 1
kallikrein B, plasma (Fletcher factor) 1
kallikrein B, plasma (Fletcher factor) 1
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
Plasma prekallikrein is a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. Plasma kallikrein therefore is composed of a heavy chain and a light chain held together by a disulphide bond. The heavy chain originates from the amino-terminal end of the zymogen and contains 4 tandem repeats of 90 or 91 amino acids. Each repeat harbors a novel structure called the apple domain. The heavy chain is required for the surface-dependent pro-coagulant activity of plasma kallikrein. The light chain contains the active site or catalytic domain of the enzyme and is homologous to the trypsin family of serine proteases. Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients. [provided by RefSeq, Jul 2008] Plasma prekallikrein is a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. Plasma kallikrein therefore is composed of a heavy chain and a light chain held together by a disulphide bond. The heavy chain originates from the amino-terminal end of the zymogen and contains 4 tandem repeats of 90 or 91 amino acids. Each repeat harbors a novel structure called the apple domain. The heavy chain is required for the surface-dependent pro-coagulant activity of plasma kallikrein. The light chain contains the active site or catalytic domain of the enzyme and is homologous to the trypsin family of serine proteases. Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 4:186208979-186258471 | ||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||
Band | q35.2 | ||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Intrinsic Pathway pathway
Activation of Matrix Metalloproteinases pathway
Extracellular matrix organization pathway
Degradation of the extracellular matrix pathway
Formation of Fibrin Clot (Clotting Cascade) pathway
Hemostasis pathway
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KEGG |
Complement and coagulation cascades pathway
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INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | C9IYG8 C9JCT1 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 3818 | ||||||||||||||||||||||
UniGene | Hs.237642 | ||||||||||||||||||||||
RefSeq | NM_000892 XM_006714213 | ||||||||||||||||||||||
HUGO | HGNC:6371 | ||||||||||||||||||||||
OMIM | 229000 | ||||||||||||||||||||||
CCDS | CCDS34120 | ||||||||||||||||||||||
HPRD | 01971 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AC110771 | ||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | 3818 | ||||||||||||||||||||||