Version 5.4
Homo sapiens Gene: KLKB1
Summary
InnateDB Gene IDBG-47494.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KLKB1
Gene Name kallikrein B, plasma (Fletcher factor) 1
Synonyms KLK3; PPK
Species Homo sapiens
Ensembl Gene ENSG00000164344
Encoded Proteins
IDBP-47496
kallikrein B, plasma (Fletcher factor) 1
IDBP-380876
kallikrein B, plasma (Fletcher factor) 1
IDBP-380884
kallikrein B, plasma (Fletcher factor) 1
IDBP-380887
kallikrein B, plasma (Fletcher factor) 1
IDBP-481314
kallikrein B, plasma (Fletcher factor) 1
IDBP-475823
kallikrein B, plasma (Fletcher factor) 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Plasma prekallikrein is a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. Plasma kallikrein therefore is composed of a heavy chain and a light chain held together by a disulphide bond. The heavy chain originates from the amino-terminal end of the zymogen and contains 4 tandem repeats of 90 or 91 amino acids. Each repeat harbors a novel structure called the apple domain. The heavy chain is required for the surface-dependent pro-coagulant activity of plasma kallikrein. The light chain contains the active site or catalytic domain of the enzyme and is homologous to the trypsin family of serine proteases. Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients. [provided by RefSeq, Jul 2008]
Plasma prekallikrein is a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. Plasma kallikrein therefore is composed of a heavy chain and a light chain held together by a disulphide bond. The heavy chain originates from the amino-terminal end of the zymogen and contains 4 tandem repeats of 90 or 91 amino acids. Each repeat harbors a novel structure called the apple domain. The heavy chain is required for the surface-dependent pro-coagulant activity of plasma kallikrein. The light chain contains the active site or catalytic domain of the enzyme and is homologous to the trypsin family of serine proteases. Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:186208979-186258471
Strand Forward strand
Band q35.2
Transcripts
ENST00000264690 ENSP00000264690
ENST00000428196 ENSP00000412366
ENST00000446598 ENSP00000415563
ENST00000414291 ENSP00000392231
ENST00000511608 ENSP00000426629
ENST00000513864 ENSP00000424469
ENST00000511406
ENST00000467271
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding
Biological Process
GO:0002542 Factor XII activation
GO:0006508 proteolysis
GO:0007596 blood coagulation
GO:0007597 blood coagulation, intrinsic pathway
GO:0022617 extracellular matrix disassembly
GO:0030198 extracellular matrix organization
GO:0031638 zymogen activation
GO:0031639 plasminogen activation
GO:0042730 fibrinolysis
GO:0051919 positive regulation of fibrinolysis
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031640
View Gene Order
ENSBTAG00000009501
Not yet available
Pathways
NETPATH
REACTOME
REACT_326
Intrinsic Pathway pathway
REACT_118682
Activation of Matrix Metalloproteinases pathway
REACT_118779
Extracellular matrix organization pathway
REACT_118572
Degradation of the extracellular matrix pathway
REACT_2051
Formation of Fibrin Clot (Clotting Cascade) pathway
REACT_604
Hemostasis pathway
KEGG
hsa04610
Complement and coagulation cascades pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL C9IYG8 C9JCT1
UniProt Splice Variant
Entrez Gene 3818
UniGene Hs.237642
RefSeq NM_000892 XM_006714213
HUGO HGNC:6371
OMIM 229000
CCDS CCDS34120
HPRD 01971
IMGT
EMBL AC110771
GenPept
RNA Seq Atlas 3818

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca