InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DNAJC24

Summary

InnateDB Protein

IDBP-474996.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DNAJC24

Protein Name

DnaJ (Hsp40) homolog, subfamily C, member 24

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000417548

InnateDB Gene

IDBG-37306 (DNAJC24)

Protein Structure

UniProt Annotation

Function

Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron-binding. The iron- bound form is redox-active and can function as electron carrier. Plays a role in the diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta). {ECO:0000269PubMed:22367199, ECO:0000269PubMed:22509046}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001671	ATPase activator activity
GO:0008198	ferrous iron binding
GO:0008270	zinc ion binding

Biological Process

GO:0017183	peptidyl-diphthamide biosynthetic process from peptidyl-histidine
GO:0032781	positive regulation of ATPase activity
GO:0055114	oxidation-reduction process
GO:0061077	chaperone-mediated protein folding