InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC26A8

Summary

InnateDB Protein

IDBP-475031.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC26A8

Protein Name

solute carrier family 26, member 8

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000417638

InnateDB Gene

IDBG-84563 (SLC26A8)

Protein Structure

UniProt Annotation

Function

Acts as a DIDS-sensitive anion exchanger mediating chloride, sulfate and oxalate transport. May fulfill critical anion exchange functions in male germ line during meiosis and hence may play a role in spermatogenesis. May be involved in a new regulatory pathway linking sulfate transport to RhoGTPase signaling in male germ cells. A critical component of the sperm annulus that is essential for correct sperm tail differentiation and motility and hence male fertility. May form a moleculer complex involved in the regulation of chloride and bicarbonate ions fluxes during sperm capacitation. {ECO:0000269PubMed:11278976, ECO:0000269PubMed:11834742, ECO:0000269PubMed:22121115}.

Subcellular Localization

Membrane {ECO:0000269PubMed:11278976, ECO:0000269PubMed:17517695}; Multi-pass membrane protein {ECO:0000269PubMed:11278976, ECO:0000269PubMed:17517695}. Note=Located at the annulus ring structure within the sperm cell. {ECO:0000269PubMed:11278976, ECO:0000269PubMed:17517695}.

Disease Associations

Spermatogenic failure 3 (SPGF3) [MIM:606766]: A disorder characterized by primary infertility, sperm morphologic abnormalities, and moderate to severe asthenozoospermia, condition in which the percentage of progressively motile sperm is abnormally low. {ECO:0000269PubMed:23582645}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expression observed exclusively in testis, restricted to the meiotic phase of the germ cell. Abundant expression located in the seminiferous tubules, concentrated on the luminal side of the tubuli harboring the spermatocytes and spermatids. Expressed in spermatozoa. {ECO:0000269PubMed:11278976, ECO:0000269PubMed:11834742}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005254	chloride channel activity
GO:0005515	protein binding
GO:0015116	sulfate transmembrane transporter activity
GO:0015301	anion:anion antiporter activity
GO:0019531	oxalate transmembrane transporter activity

Biological Process

GO:0006820	anion transport
GO:0006821	chloride transport
GO:0007126	meiotic nuclear division
GO:0007275	multicellular organismal development
GO:0007283	spermatogenesis
GO:0008272	sulfate transport
GO:0019532	oxalate transport
GO:0030154	cell differentiation
GO:1902358	sulfate transmembrane transport
GO:1902476	chloride transmembrane transport