InnateDB Protein
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IDBP-475044.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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RNF19A
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Protein Name
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ring finger protein 19A
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Synonyms
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RNF19;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000429161
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InnateDB Gene
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IDBG-30691 (RNF19A)
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Protein Structure
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Function |
E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR. Specifically ubiquitinates pathogenic SOD1 variants, which leads to their proteasomal degradation and to neuronal protection. {ECO:0000269PubMed:11237715, ECO:0000269PubMed:12145308, ECO:0000269PubMed:12750386, ECO:0000269PubMed:15456787, ECO:0000269PubMed:16513638}.
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Subcellular Localization |
Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:11237715, ECO:0000269PubMed:12145308, ECO:0000269PubMed:12750386, ECO:0000269PubMed:15456787}. Note=Present in the hyaline inclusion bodies specifically found in motor neurons from amyotrophic lateral sclerosis patients. Present in the Lewy bodies specifically found in neurons from Parkinson disease patients.
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Disease Associations |
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Tissue Specificity |
Widely expressed, with highest levels in heart. Ubiquitously expressed in the central nervous system. {ECO:0000269PubMed:11237715}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated |
Total |
22
[view]
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Protein-Protein |
22
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
5 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9NV58
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PhosphoSite |
PhosphoSite-Q9NV58
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
25897
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UniGene |
Hs.735657
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RefSeq |
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HUGO |
HGNC:13432
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OMIM |
607119
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CCDS |
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HPRD |
06176
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IMGT |
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EMBL |
AB029316
AB271914
AJ242975
AK001774
AK023455
AK027070
AL110253
AL122096
BC093938
BC093940
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GenPept |
AAH93938
AAH93940
BAA91900
BAB14581
BAB15647
BAB39353
BAF48117
CAB45132
CAB53700
CAB59264
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