InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UBE2W

Summary

InnateDB Protein

IDBP-475128.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UBE2W

Protein Name

ubiquitin-conjugating enzyme E2W (putative)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000428813

InnateDB Gene

IDBG-25727 (UBE2W)

Protein Structure

UniProt Annotation

Function

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in degradation of misfolded chaperone substrates by mediating monoubiquitination of STUB1/CHIP, leading to recruitment of ATXN3 to monoubiquitinated STUB1/CHIP, and restriction of the length of ubiquitin chain attached to STUB1/CHIP substrates by ATXN3. After UV irradiation, but not after mitomycin-C (MMC) treatment, acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Transfers ubiquitin in complex with RING/U-box type E3s that do not have active site cysteine residues to form thioester bonds with ubiquitin, and preferentially ubiquitinates the N-terminus of substrates, such as ATXN3, STUB1 and SUMO2. {ECO:0000269PubMed:19111657, ECO:0000269PubMed:20061386, ECO:0000269PubMed:21229326, ECO:0000269PubMed:23560854, ECO:0000269PubMed:23696636}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:16368532}. Note=In the nucleus, colocalizes with FANCL.

Disease Associations

Tissue Specificity

Widely expressed, with highest expression in brain, liver, pancreas and heart. {ECO:0000269PubMed:16368532}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 75 experimentally validated interaction(s) in this database.

Experimentally validated
Total	75 [view]
Protein-Protein	74 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005524	ATP binding
GO:0016881	acid-amino acid ligase activity
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0006281	DNA repair
GO:0006513	protein monoubiquitination
GO:0006515	misfolded or incompletely synthesized protein catabolic process
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070979	protein K11-linked ubiquitination
GO:0071218	cellular response to misfolded protein