InnateDB Protein
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IDBP-475153.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MMEL1
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Protein Name
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membrane metallo-endopeptidase-like 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000425477
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InnateDB Gene
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IDBG-86465 (MMEL1)
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Protein Structure
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Function |
Metalloprotease involved in sperm function, possibly by modulating the processes of fertilization and early embryonic development. Degrades a broad variety of small peptides with a preference for peptides shorter than 3 kDa containing neutral bulky aliphatic or aromatic amino acid residues. Shares the same substrate specificity with MME and cleaves peptides at the same amide bond (By similarity). {ECO:0000250}.
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Subcellular Localization |
Membrane; Single-pass type II membrane protein. Secreted. Note=A secreted form produced by proteollytic cleavage also exists. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Predominantly expressed in testis. Weakly expressed in brain, kidney and heart. {ECO:0000269PubMed:11560781}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR008753
Peptidase M13, N-terminal domain
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PFAM |
PF05649
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q495T6
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PhosphoSite |
PhosphoSite-Q495T6
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
79258
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UniGene |
Hs.591453
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RefSeq |
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HUGO |
HGNC:14668
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OMIM |
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CCDS |
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HPRD |
07024
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IMGT |
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EMBL |
AF336981
AL139246
AL589746
AL831784
BC101027
BC101028
BC101029
BC101030
CH471183
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GenPept |
AAI01028
AAI01029
AAI01030
AAI01031
AAL08942
CAI17336
CAI22652
CAX30814
EAW56082
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