Version 5.4
Homo sapiens Protein: GRHL1
Summary
InnateDB Protein IDBP-475203.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GRHL1
Protein Name grainyhead-like 1 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000418275
InnateDB Gene IDBG-28061 (GRHL1)
Protein Structure
UniProt Annotation
Function Transcription factor. Isoform 1 may function as an activator and isoform 2 as a repressor in tissues where both forms are expressed. May play a role in development. May be involved in epidermal differentiation (By similarity). Binds and transactivates the EN1 promoter. {ECO:0000250, ECO:0000269PubMed:12175488}.
Subcellular Localization Nucleus.
Disease Associations
Tissue Specificity Isoform 1 is highly expressed in brain, pancreas, tonsil, placenta and kidney. Isoform 2 is highly expressed in brain and liver. Highly expressed in placental JEG-3 cells and at very low levels in non-steroidogenic cells. No expression detected in adrenal NCI-H295A cells. {ECO:0000269PubMed:10644752, ECO:0000269PubMed:12175488}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007275 multicellular organismal development
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0043231 intracellular membrane-bounded organelle
Protein Structure and Domains
PDB ID
InterPro IPR007604 CP2 transcription factor
PFAM PF04516
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NZI5
PhosphoSite PhosphoSite-Q9NZI5
TrEMBL F8WFB0
UniProt Splice Variant
Entrez Gene 29841
UniGene Hs.418493
RefSeq
HUGO HGNC:17923
OMIM 609786
CCDS
HPRD 18176
IMGT
EMBL AC010969 AF198489 AF411210 AK312950 BC067519 BC067520 BC067521 CH471053
GenPept AAF32276 AAH67519 AAH67520 AAH67521 AAM22616 AAX93273 BAG35791 EAX00973

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca