InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CALCA

Summary

InnateDB Protein

IDBP-475273.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CALCA

Protein Name

calcitonin-related polypeptide alpha

Synonyms

CALC1; CGRP; CGRP-I; CGRP1; CT; KC;

Species

Homo sapiens

Ensembl Protein

ENSP00000417833

InnateDB Gene

IDBG-33289 (CALCA)

Protein Structure

UniProt Annotation

Function

CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP. {ECO:0000269PubMed:1318039}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005179	hormone activity
GO:0005515	protein binding
GO:0032403	protein complex binding

Biological Process

GO:0001935	endothelial cell proliferation
GO:0001944	vasculature development
GO:0001976	neurological system process involved in regulation of systemic arterial blood pressure
GO:0002031	G-protein coupled receptor internalization
GO:0006468	protein phosphorylation
GO:0007159	leukocyte cell-cell adhesion
GO:0007190	activation of adenylate cyclase activity
GO:0007267	cell-cell signaling
GO:0008217	regulation of blood pressure
GO:0010523	negative regulation of calcium ion transport into cytosol
GO:0030819	positive regulation of cAMP biosynthetic process
GO:0031623	receptor internalization
GO:0032730	positive regulation of interleukin-1 alpha production
GO:0032757	positive regulation of interleukin-8 production
GO:0043542	endothelial cell migration
GO:0045087	innate immune response (InnateDB)
GO:0045651	positive regulation of macrophage differentiation
GO:0045671	negative regulation of osteoclast differentiation
GO:0045776	negative regulation of blood pressure
GO:0045779	negative regulation of bone resorption
GO:0045909	positive regulation of vasodilation
GO:0051480	cytosolic calcium ion homeostasis
GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000443 Pro-islet amyloid polypeptide
IPR001693 Calcitonin peptide-like
IPR015476 Calcitonin gene-related peptide
IPR021116 Procalcitonin/adrenomedullin

PFAM

PF00214

PRINTS

PR00818
PR00817

PIRSF

SMART

SM00113

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt