InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NAIP

Summary

InnateDB Protein

IDBP-475282.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NAIP

Protein Name

NLR family, apoptosis inhibitory protein

Synonyms

BIRC1; NLRB1; psiNAIP;

Species

Homo sapiens

Ensembl Protein

ENSP00000424913

InnateDB Gene

IDBG-402309 (NAIP)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0017111	nucleoside-triphosphatase activity
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0046872	metal ion binding

Biological Process

GO:0006954	inflammatory response
GO:0007399	nervous system development
GO:0008152	metabolic process
GO:0043066	negative regulation of apoptotic process
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043524	negative regulation of neuron apoptotic process
GO:0045087	innate immune response

Cellular Component

GO:0005737	cytoplasm
GO:0016323	basolateral plasma membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001370 Baculoviral inhibition of apoptosis protein repeat
IPR003593 AAA+ ATPase domain
IPR007111 NACHT nucleoside triphosphatase
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00653

PRINTS

PIRSF

SMART

SM00238
SM00382

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q13075