InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NR3C2

Summary

InnateDB Protein

IDBP-475383.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NR3C2

Protein Name

nuclear receptor subfamily 3, group C, member 2

Synonyms

MCR; MLR; MR; NR3C2VIT;

Species

Homo sapiens

Ensembl Protein

ENSP00000421481

InnateDB Gene

IDBG-40591 (NR3C2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	33 [view]
Protein-Protein	31 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0005496	steroid binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0007165	signal transduction
GO:0010467	gene expression
GO:0043401	steroid hormone mediated signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005789	endoplasmic reticulum membrane
GO:0043235	receptor complex

Protein Structure and Domains

PDB ID

InterPro

IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001628 Zinc finger, nuclear hormone receptor-type
IPR008946 Nuclear hormone receptor, ligand-binding

PFAM

PF00104
PF00105

PRINTS

PR00047

PIRSF

SMART

SM00430
SM00399

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt