Homo sapiens Protein: ZNF346
Summary
InnateDB Protein IDBP-475475.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZNF346
Protein Name zinc finger protein 346
Synonyms JAZ; Zfp346;
Species Homo sapiens
Ensembl Protein ENSP00000424495
InnateDB Gene IDBG-59400 (ZNF346)
Protein Structure
UniProt Annotation
Function Binds with low affinity to dsDNA and ssRNA, and with high affinity to dsRNA, with no detectable sequence specificity. {ECO:0000269PubMed:24521053}.
Subcellular Localization Nucleus, nucleolus {ECO:0000269PubMed:15254228}. Cytoplasm {ECO:0000269PubMed:15254228}. Note=Nuclear at steady state, primarily in the nucleolus. Shuttles between the nucleus and cytoplasm when associated with XPO5.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 34 [view]
Protein-Protein 33 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003725 double-stranded RNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0019899 enzyme binding
GO:0044822 poly(A) RNA binding
Biological Process
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR003604 Zinc finger, U1-type
IPR015880 Zinc finger, C2H2-like
PFAM
PRINTS
PIRSF
SMART SM00451
SM00355
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UL40
PhosphoSite PhosphoSite-Q9UL40
TrEMBL
UniProt Splice Variant
Entrez Gene 23567
UniGene Hs.484259
RefSeq
HUGO HGNC:16403
OMIM 605308
CCDS
HPRD 05606
IMGT
EMBL AC027314 AC027317 AF083340 AK131469 AK295549 BC007775 CR749692
GenPept AAD52018 AAH07775 BAD18614 BAH12103 CAH18475