Version 5.4
Homo sapiens Gene: ZNF346
Summary
InnateDB Gene IDBG-59400.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZNF346
Gene Name zinc finger protein 346
Synonyms JAZ; Zfp346
Species Homo sapiens
Ensembl Gene ENSG00000113761
Encoded Proteins
IDBP-59404
zinc finger protein 346
IDBP-482078
zinc finger protein 346
IDBP-479852
zinc finger protein 346
IDBP-474354
zinc finger protein 346
IDBP-473516
zinc finger protein 346
IDBP-477735
zinc finger protein 346
IDBP-473868
zinc finger protein 346
IDBP-475475
zinc finger protein 346
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a nucleolar, zinc finger protein that preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids, rather than DNA alone. Mutational studies indicate that the zinc finger domains are not only essential for dsRNA binding, but are also required for its nucleolar localization. The encoded protein may be involved in cell growth and survival. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:177022696-177081189
Strand Forward strand
Band q35.2
Transcripts
ENST00000358149 ENSP00000350869
ENST00000506693 ENSP00000423515
ENST00000512315 ENSP00000421089
ENST00000503425 ENSP00000421212
ENST00000508155 ENSP00000421388
ENST00000511834 ENSP00000425725
ENST00000513587 ENSP00000423690
ENST00000503039 ENSP00000424495
ENST00000510933
ENST00000504600
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 34 [view]
Protein-Protein 33 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003725 double-stranded RNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0019899 enzyme binding
GO:0044822 poly(A) RNA binding
GO:0046872 metal ion binding
Biological Process
GO:0043065 positive regulation of apoptotic process
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021481
View Gene Order
ENSBTAG00000010541
Not yet available
Cross-References
SwissProt
TrEMBL D6RJ07
UniProt Splice Variant
Entrez Gene 23567
UniGene Hs.484259
RefSeq XM_005265860 XM_005265862 NM_012279 XM_006714837
HUGO HGNC:16403
OMIM 605308
CCDS CCDS4409
HPRD 05606
IMGT
EMBL AC027314 AC027317
GenPept
RNA Seq Atlas 23567

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca