Version 5.4
Homo sapiens Protein: LUC7L3
Summary
InnateDB Protein IDBP-475835.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LUC7L3
Protein Name LUC7-like 3 (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000425092
InnateDB Gene IDBG-59253 (LUC7L3)
Protein Structure
UniProt Annotation
Function Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing. {ECO:0000269PubMed:16462885}.
Subcellular Localization Nucleus speckle {ECO:0000269PubMed:10631324, ECO:0000269PubMed:12565863}. Note=The subnuclear localization is affected by cisplatin.
Disease Associations
Tissue Specificity Widely expressed. Highest levels in heart, brain, pancreas, thymus, ovary, small intestine and peripheral blood leukocytes, as well as cerebellum, putamen and pituitary gland. Lowest levels in lung, liver and kidney. Also expressed in fetal tissues, including brain, heart, kidney, thymus and lung. {ECO:0000269PubMed:10631324, ECO:0000269PubMed:16462885}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 45 [view]
Protein-Protein 43 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003729 mRNA binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006376 mRNA splice site selection
GO:0008380 RNA splicing
Cellular Component
GO:0005634 nucleus
GO:0005685 U1 snRNP
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0016607 nuclear speck
Protein Structure and Domains
PDB ID
InterPro IPR004882 Luc7-related
PFAM PF03194
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O95232
PhosphoSite PhosphoSite-O95232
TrEMBL U3KQT3
UniProt Splice Variant
Entrez Gene 51747
UniGene Hs.735319
RefSeq NP_057508
HUGO HGNC:24309
OMIM 609434
CCDS CCDS11573
HPRD 16759
IMGT
EMBL AB034205 AC005921 AF069250 AK001925 AK023672 BC056409 CH471109 DQ013876
GenPept AAC79807 AAH56409 AAY26238 BAA90542 BAA91981 BAG51216 EAW94583 EAW94585 EAW94587

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca