InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: LUC7L3

Summary

InnateDB Gene

IDBG-59253.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LUC7L3

Gene Name

LUC7-like 3 (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000108848

Encoded Proteins

IDBP-59255

LUC7-like 3 (S. cerevisiae)

IDBP-244045

LUC7-like 3 (S. cerevisiae)

IDBP-475835

LUC7-like 3 (S. cerevisiae)

IDBP-473401

LUC7-like 3 (S. cerevisiae)

IDBP-484697

LUC7-like 3 (S. cerevisiae)

IDBP-483029

LUC7-like 3 (S. cerevisiae)

IDBP-483286

LUC7-like 3 (S. cerevisiae)

IDBP-480455

LUC7-like 3 (S. cerevisiae)

IDBP-483203

LUC7-like 3 (S. cerevisiae)

IDBP-484582

LUC7-like 3 (S. cerevisiae)

IDBP-482663

LUC7-like 3 (S. cerevisiae)

IDBP-811413

LUC7-like 3 (S. cerevisiae)

IDBP-478167

LUC7-like 3 (S. cerevisiae)

IDBP-484215

LUC7-like 3 (S. cerevisiae)

IDBP-483204

LUC7-like 3 (S. cerevisiae)

IDBP-475171

LUC7-like 3 (S. cerevisiae)

IDBP-476130

LUC7-like 3 (S. cerevisiae)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a protein with an N-terminal half that contains cysteine/histidine motifs and leucine zipper-like repeats, and the C-terminal half is rich in arginine and glutamate residues (RE domain) and arginine and serine residues (RS domain). This protein localizes with a speckled pattern in the nucleus, and could be involved in the formation of splicesome via the RE and RS domains. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:50719544-50756213

Strand

Forward strand

Band

q21.33

Transcripts

ENST00000240304	ENSP00000240304
ENST00000393227	ENSP00000376919
ENST00000505658	ENSP00000425092
ENST00000508045	ENSP00000424788
ENST00000508218
ENST00000506686	ENSP00000426488
ENST00000509335	ENSP00000425251
ENST00000504563	ENSP00000424767
ENST00000505619	ENSP00000420933
ENST00000508482	ENSP00000421213
ENST00000510984	ENSP00000426123
ENST00000507200	ENSP00000423556
ENST00000513025	ENSP00000476198
ENST00000507503
ENST00000511068
ENST00000504065	ENSP00000426371
ENST00000509487	ENSP00000428293
ENST00000511974	ENSP00000428225
ENST00000513969	ENSP00000427927
ENST00000503728	ENSP00000430407
ENST00000512549
ENST00000503798

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	45 [view]
Protein-Protein	43 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003729	mRNA binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006376	mRNA splice site selection
GO:0008380	RNA splicing

Cellular Component

GO:0005634	nucleus
GO:0005685	U1 snRNP
GO:0005886	plasma membrane
GO:0005925	focal adhesion
GO:0016607	nuclear speck

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000020863

View Gene Order

ENSBTAG00000002279

Not yet available

Cross-References

SwissProt

TrEMBL

D6RDI2 D6RHH0 U3KQT3

UniProt Splice Variant

Entrez Gene

51747

UniGene

Hs.130293 Hs.597400 Hs.655691 Hs.712882 Hs.735319

RefSeq

NM_006107 NM_016424 XM_005257448 XM_005257455

HUGO

HGNC:24309

OMIM

609434

CCDS

CCDS11573

HPRD

16759

IMGT

EMBL

AC005921

GenPept

RNA Seq Atlas

51747