Version 5.4
Homo sapiens Protein: ARHGEF26
Summary
InnateDB Protein IDBP-475836.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARHGEF26
Protein Name Rho guanine nucleotide exchange factor (GEF) 26
Synonyms CSGEF; HMFN1864; SGEF;
Species Homo sapiens
Ensembl Protein ENSP00000423295
InnateDB Gene IDBG-61957 (ARHGEF26)
Protein Structure
UniProt Annotation
Function Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry. {ECO:0000269PubMed:15133129, ECO:0000269PubMed:17074883, ECO:0000269PubMed:17875742}.
Subcellular Localization Cell projection, ruffle {ECO:0000269PubMed:15133129, ECO:0000269PubMed:17875742}.
Disease Associations
Tissue Specificity Isoform 1 is broadly expressed, with highest levels in liver (at protein level). Certain mRNA species appear to be specifically expressed in prostate and liver. {ECO:0000269PubMed:12697679, ECO:0000269PubMed:15133129}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005089 Rho guanyl-nucleotide exchange factor activity
Biological Process
GO:0032321 positive regulation of Rho GTPase activity
Cellular Component
GO:0001726 ruffle
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96DR7
PhosphoSite PhosphoSite-Q96DR7
TrEMBL
UniProt Splice Variant
Entrez Gene 26084
UniGene Hs.608994
RefSeq
HUGO HGNC:24490
OMIM
CCDS
HPRD 11554
IMGT
EMBL AB073386 AC018452 AF415175 AF415176 AK022655 AK022884 AK123040 AL117429 AY552599 BC016628 BC078655 FJ695204
GenPept AAH16628 AAH78655 AAL27001 AAL27002 AAS59842 BAB14159 BAB14292 BAD38637 BAG53860 CAB55918

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca