Version 5.4
Homo sapiens Gene: ARHGEF26
Summary
InnateDB Gene IDBG-61957.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARHGEF26
Gene Name Rho guanine nucleotide exchange factor (GEF) 26
Synonyms CSGEF; HMFN1864; SGEF
Species Homo sapiens
Ensembl Gene ENSG00000114790
Encoded Proteins
IDBP-61959
Rho guanine nucleotide exchange factor (GEF) 26
IDBP-481239
Rho guanine nucleotide exchange factor (GEF) 26
IDBP-480370
Rho guanine nucleotide exchange factor (GEF) 26
IDBP-475836
Rho guanine nucleotide exchange factor (GEF) 26
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the Rho-guanine nucleotide exchange factor (Rho-GEF) family. These proteins regulate Rho GTPases by catalyzing the exchange of GDP for GTP. The encoded protein specifically activates RhoG and plays a role in the promotion of macropinocytosis. Underexpression of the encoded protein may be a predictive marker of chemoresistant disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:154121003-154257827
Strand Forward strand
Band q25.2
Transcripts
ENST00000356448 ENSP00000348828
ENST00000465093 ENSP00000423418
ENST00000496710 ENSP00000424446
ENST00000465817 ENSP00000423295
ENST00000483068
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
Biological Process
GO:0001886 endothelial cell morphogenesis
GO:0032321 positive regulation of Rho GTPase activity
GO:0035023 regulation of Rho protein signal transduction
GO:0097178 ruffle assembly
Cellular Component
GO:0001726 ruffle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000036885
View Gene Order
ENSBTAG00000013439
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa05100
Bacterial invasion of epithelial cells pathway
INOH
PID NCI
Cross-References
SwissProt Q96DR7
TrEMBL
UniProt Splice Variant
Entrez Gene 26084
UniGene Hs.240845 Hs.608994
RefSeq NM_001251963 NM_015595 NM_001251962 XM_005247324
HUGO HGNC:24490
OMIM
CCDS CCDS46938 CCDS58858
HPRD 11554
IMGT
EMBL AB073386 AC018452 AF415175 AF415176 AK022655 AK022884 AK123040 AL117429 AY552599 BC016628 BC078655 FJ695204
GenPept AAH16628 AAH78655 AAL27001 AAL27002 AAS59842 BAB14159 BAB14292 BAD38637 BAG53860 CAB55918
RNA Seq Atlas 26084

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca