InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ENO3

Summary

InnateDB Protein

IDBP-475869.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ENO3

Protein Name

enolase 3 (beta, muscle)

Synonyms

GSD13; MSE;

Species

Homo sapiens

Ensembl Protein

ENSP00000430636

InnateDB Gene

IDBG-20436 (ENO3)

Protein Structure

UniProt Annotation

Function

Appears to have a function in striated muscle development and regeneration.

Subcellular Localization

Cytoplasm. Note=Localized to the Z line. Some colocalization with CKM at M-band (By similarity). {ECO:0000250}.

Disease Associations

Glycogen storage disease 13 (GSD13) [MIM:612932]: A metabolic disorder that results in exercise-induced myalgias, generalized muscle weakness and fatigability. It is characterized by increased serum creatine kinase and decreased enolase 3 activity. Dramatically reduced protein levels with focal sarcoplasmic accumulation of glycogen-beta particles are detected on ultrastructural analysis. {ECO:0000269PubMed:11506403}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

The alpha/alpha homodimer is expressed in embryo and in most adult tissues. The alpha/beta heterodimer and the beta/beta homodimer are found in striated muscle, and the alpha/gamma heterodimer and the gamma/gamma homodimer in neurons.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004634	phosphopyruvate hydratase activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006006	glucose metabolic process
GO:0006094	gluconeogenesis
GO:0006096	glycolytic process
GO:0044281	small molecule metabolic process

Cellular Component

GO:0000015	phosphopyruvate hydratase complex
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000941 Enolase
IPR020810 Enolase, C-terminal
IPR020811 Enolase, N-terminal
IPR022662 Methylaspartate ammonia-lyase, C-terminal
IPR029017 Enolase N-terminal domain-like
IPR029065 Enolase C-terminal domain-like

PFAM

PF00113
PF03952
PF07476

PRINTS

PR00148

PIRSF

PIRSF001400

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt