InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ENO3

Summary

InnateDB Gene

IDBG-20436.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ENO3

Gene Name

enolase 3 (beta, muscle)

Synonyms

GSD13; MSE

Species

Homo sapiens

Ensembl Gene

ENSG00000108515

Encoded Proteins

IDBP-20440

enolase 3 (beta, muscle)

IDBP-764888

IDBP-761317

IDBP-475069

enolase 3 (beta, muscle)

IDBP-758392

IDBP-764951

IDBP-483181

enolase 3 (beta, muscle)

IDBP-484139

enolase 3 (beta, muscle)

IDBP-477484

enolase 3 (beta, muscle)

IDBP-475869

enolase 3 (beta, muscle)

IDBP-479416

enolase 3 (beta, muscle)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes one of the three enolase isoenzymes found in mammals. This isoenzyme is found in skeletal muscle cells in the adult where it may play a role in muscle development and regeneration. A switch from alpha enolase to beta enolase occurs in muscle tissue during development in rodents. Mutations in this gene have be associated glycogen storage disease. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Jul 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:4948092-4957131

Strand

Forward strand

Band

p13.2

Transcripts

ENST00000323997	ENSP00000324105
ENST00000519266	ENSP00000467270
ENST00000520221	ENSP00000467444
ENST00000522798	ENSP00000428502
ENST00000522301	ENSP00000465697
ENST00000521811	ENSP00000464874
ENST00000519602	ENSP00000430055
ENST00000518972
ENST00000519834
ENST00000522249	ENSP00000428811
ENST00000521659	ENSP00000430554
ENST00000519584	ENSP00000430636
ENST00000519300
ENST00000518175	ENSP00000431087
ENST00000522425
ENST00000522954
ENST00000571235

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004634	phosphopyruvate hydratase activity
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006006	glucose metabolic process
GO:0006094	gluconeogenesis
GO:0006096	glycolytic process
GO:0007568	aging
GO:0021762	substantia nigra development
GO:0042493	response to drug
GO:0043403	skeletal muscle tissue regeneration
GO:0044281	small molecule metabolic process

Cellular Component

GO:0000015	phosphopyruvate hydratase complex
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane