Version 5.4
Homo sapiens Protein: GPBAR1
Summary
InnateDB Protein IDBP-475935.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GPBAR1
Protein Name G protein-coupled bile acid receptor 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000428824
InnateDB Gene IDBG-80852 (GPBAR1)
Protein Structure
UniProt Annotation
Function Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids. {ECO:0000269PubMed:12419312, ECO:0000269PubMed:12524422}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:12524422}; Multi-pass membrane protein {ECO:0000269PubMed:12524422}.
Disease Associations
Tissue Specificity Ubiquitously expressed. Expressed at higher level in spleen and placenta. Expressed at lower level in other tissues. In digestive tissues, it is expressed in stomach, duodenum, ileocecum, ileum, jejunum, ascending colon, transverse colon, descending colon, cecum and liver, but not in esophagus and rectum. {ECO:0000269PubMed:12044878, ECO:0000269PubMed:12419312, ECO:0000269PubMed:12524422}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0038181 bile acid receptor activity
GO:0038182 G-protein coupled bile acid receptor activity
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0038184 cell surface bile acid receptor signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
IPR017452 GPCR, rhodopsin-like, 7TM
PFAM PF00001
PRINTS PR00237
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8TDU6
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 151306
UniGene Hs.160954
RefSeq
HUGO HGNC:19680
OMIM 610147
CCDS CCDS46515
HPRD 17050
IMGT
EMBL AB083601 AB086170 AB089307 AK122658 AK122660 BC033625 CH471063
GenPept AAH33625 BAB89314 BAC55235 BAC65343 BAG53647 BAG53648 EAW70598

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca