Version 5.4
Homo sapiens Protein: GPX5
Summary
InnateDB Protein IDBP-476020.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GPX5
Protein Name glutathione peroxidase 5 (epididymal androgen-related protein)
Synonyms HEL-S-75p;
Species Homo sapiens
Ensembl Protein ENSP00000419935
InnateDB Gene IDBG-300364 (GPX5)
Protein Structure
UniProt Annotation
Function Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Epididymis.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004602 glutathione peroxidase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0006979 response to oxidative stress
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID
InterPro IPR000889 Glutathione peroxidase
IPR012336 Thioredoxin-like fold
PFAM PF00255
PF13098
PF13192
PF13462
PF13905
PRINTS PR01011
PIRSF PIRSF000303
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O75715
PhosphoSite PhosphoSite-
TrEMBL B3KS91
UniProt Splice Variant
Entrez Gene 2880
UniGene
RefSeq NP_003987
HUGO HGNC:4557
OMIM 603435
CCDS CCDS4653
HPRD 11941
IMGT
EMBL AJ005277 AK093099 AL049543 AY882013 BC128159 BC128160 CH471081
GenPept AAI28160 AAI28161 AAW56939 BAG52653 CAA06463 CAB71121 EAX03168

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca