Version 5.4
| Homo sapiens Gene: GPX5 | |||||||||
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| Summary | |||||||||
| InnateDB Gene | IDBG-300364.3 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | GPX5 | ||||||||
| Gene Name | glutathione peroxidase 5 (epididymal androgen-related protein) | ||||||||
| Synonyms | HEL-S-75p | ||||||||
| Species | Homo sapiens | ||||||||
| Ensembl Gene | ENSG00000224586 | ||||||||
| Encoded Proteins |
glutathione peroxidase 5 (epididymal androgen-related protein)
glutathione peroxidase 5 (epididymal androgen-related protein)
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||
| Entrez Gene | |||||||||
| Summary |
This gene belongs to the glutathione peroxidase family. It is specifically expressed in the epididymis in the mammalian male reproductive tract, and is androgen-regulated. Unlike mRNAs for other characterized glutathione peroxidases, this mRNA does not contain a selenocysteine (UGA) codon. Thus, the encoded protein is selenium-independent, and has been proposed to play a role in protecting the membranes of spermatozoa from the damaging effects of lipid peroxidation and/or preventing premature acrosome reaction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2008] |
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| Gene Information | |||||||||
| Type | Protein coding | ||||||||
| Genomic Location | Chromosome 6:28525925-28534952 | ||||||||
| Strand | Forward strand | ||||||||
| Band | p22.1 | ||||||||
| Transcripts |
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| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||
| NETPATH | |||||||||
| REACTOME | |||||||||
| KEGG |
Arachidonic acid metabolism pathway
Glutathione metabolism pathway
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| INOH | |||||||||
| PID NCI | |||||||||
| Cross-References | |||||||||
| SwissProt | O75715 | ||||||||
| TrEMBL | B3KS91 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 2880 | ||||||||
| UniGene | |||||||||
| RefSeq | NM_003996 NM_001509 | ||||||||
| HUGO | HGNC:4557 | ||||||||
| OMIM | 603435 | ||||||||
| CCDS | CCDS4653 CCDS4652 | ||||||||
| HPRD | 11941 | ||||||||
| IMGT | |||||||||
| EMBL | AJ005277 AK093099 AL049543 AY882013 BC128159 BC128160 CH471081 | ||||||||
| GenPept | AAI28160 AAI28161 AAW56939 BAG52653 CAA06463 CAB71121 EAX03168 | ||||||||
| RNA Seq Atlas | 2880 | ||||||||