InnateDB Protein
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IDBP-47626.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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KCNMB4
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Protein Name
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potassium large conductance calcium-activated channel, subfamily M, beta member 4
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000258111
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InnateDB Gene
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IDBG-47624 (KCNMB4)
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Protein Structure
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Function |
Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. May decrease KCNMA1 channel openings at low calcium concentrations but increases channel openings at high calcium concentrations. Makes KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concentrations. {ECO:0000269PubMed:10692449, ECO:0000269PubMed:10792058, ECO:0000269PubMed:10828459}.
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Subcellular Localization |
Membrane; Multi-pass membrane protein.
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Disease Associations |
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Tissue Specificity |
Predominantly expressed in brain. In brain, it is expressed in the cerebellum, cerebral cortex, medulla, spinal cord, occipital pole, frontal lobe, temporal lobe, putamen, amygdala, caudate nucleus, corpus callosum, hippocampus, substantia nigra and thalamus. Weakly or not expressed in other tissues. {ECO:0000269PubMed:10692449, ECO:0000269PubMed:10828459}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
Accession |
GO Term |
GO:0005515
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protein binding
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GO:0015269
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calcium-activated potassium channel activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR003930
Potassium channel, calcium-activated, BK, beta subunit
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PFAM |
PF03185
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PRINTS |
PR01450
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q86W47
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PhosphoSite |
PhosphoSite-Q86W47
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
27345
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UniGene |
Hs.598920
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RefSeq |
NP_055320
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HUGO |
HGNC:6289
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OMIM |
605223
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CCDS |
CCDS8997
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HPRD |
05564
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IMGT |
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EMBL |
AF160967
AF170917
AF207992
AF215891
BC042446
BC050621
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GenPept |
AAF28333
AAF69805
AAF75596
AAF89699
AAH42446
AAH50621
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