Version 5.4
Homo sapiens Gene: KCNMB4
Summary
InnateDB Gene IDBG-47624.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KCNMB4
Gene Name potassium large conductance calcium-activated channel, subfamily M, beta member 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000135643
Encoded Proteins
IDBP-47626
potassium large conductance calcium-activated channel, subfamily M, beta member 4
IDBP-598354
potassium large conductance calcium-activated channel, subfamily M, beta member 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which slows activation kinetics, leads to steeper calcium sensitivity, and shifts the voltage range of current activation to more negative potentials than does the beta 1 subunit. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:70366276-70434292
Strand Forward strand
Band q15
Transcripts
ENST00000258111 ENSP00000258111
ENST00000531884 ENSP00000431137
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0015269 calcium-activated potassium channel activity
Biological Process
GO:0001508 action potential
GO:0005513 detection of calcium ion
GO:0006813 potassium ion transport
GO:0007268 synaptic transmission
GO:0007596 blood coagulation
GO:0019228 neuronal action potential
GO:0019229 regulation of vasoconstriction
GO:0046928 regulation of neurotransmitter secretion
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0008076 voltage-gated potassium channel complex
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000054934
View Gene Order
ENSBTAG00000003749
Not yet available
Pathways
NETPATH
REACTOME
REACT_23767
cGMP effects pathway
REACT_23862
Nitric oxide stimulates guanylate cyclase pathway
REACT_23876
Platelet homeostasis pathway
REACT_75896
Ca2+ activated K+ channels pathway
REACT_13685
Neuronal System pathway
REACT_75908
Potassium Channels pathway
REACT_604
Hemostasis pathway
KEGG
hsa04270
Vascular smooth muscle contraction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.525529 Hs.598920
RefSeq NM_014505
HUGO
OMIM
CCDS CCDS8997
HPRD 05564
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca