InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC7A2

Summary

InnateDB Protein

IDBP-476318.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC7A2

Protein Name

solute carrier family 7 (cationic amino acid transporter, y+ system), member 2

Synonyms

ATRC2; CAT2; HCAT2;

Species

Homo sapiens

Ensembl Protein

ENSP00000430464

InnateDB Gene

IDBG-8686 (SLC7A2)

Protein Structure

UniProt Annotation

Function

Low-affinity, high capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine). Plays a regulatory role in classical or alternative activation of macrophages (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Expressed at high levels in the skeletal muscle, placenta and ovary. Expressed at intermediate levels in the liver and pancreas and at low levels in the kidney and heart. {ECO:0000269PubMed:8954799}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0015171	amino acid transmembrane transporter activity
GO:0015174	basic amino acid transmembrane transporter activity

Biological Process

GO:0003333	amino acid transmembrane transport
GO:0006520	cellular amino acid metabolic process
GO:0006810	transport
GO:0006811	ion transport
GO:0006865	amino acid transport
GO:0055085	transmembrane transport