Version 5.4
Homo sapiens Gene: SLC7A2
Summary
InnateDB Gene IDBG-8686.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC7A2
Gene Name solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
Synonyms ATRC2; CAT2; HCAT2
Species Homo sapiens
Ensembl Gene ENSG00000003989
Encoded Proteins
IDBP-8690
solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
IDBP-233886
solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
IDBP-485400
solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
IDBP-476318
solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
IDBP-478008
solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a cationic amino acid transporter and a member of the APC (amino acid-polyamine-organocation) family of transporters. The encoded membrane protein is responsible for the cellular uptake of arginine, lysine and ornithine. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:17497088-17570573
Strand Forward strand
Band p22
Transcripts
ENST00000004531 ENSP00000004531
ENST00000398090 ENSP00000381164
ENST00000494857 ENSP00000419140
ENST00000522656 ENSP00000430464
ENST00000470360 ENSP00000419873
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000064 L-ornithine transmembrane transporter activity
GO:0005289 high affinity arginine transmembrane transporter activity
GO:0015171 amino acid transmembrane transporter activity
GO:0015174 basic amino acid transmembrane transporter activity
GO:0015179 L-amino acid transmembrane transporter activity
GO:0015181 arginine transmembrane transporter activity
GO:0015189 L-lysine transmembrane transporter activity
Biological Process
GO:0002537 nitric oxide production involved in inflammatory response
GO:0003333 amino acid transmembrane transport
GO:0006520 cellular amino acid metabolic process
GO:0006809 nitric oxide biosynthetic process
GO:0006810 transport
GO:0006811 ion transport
GO:0006865 amino acid transport
GO:0015807 L-amino acid transport
GO:0015809 arginine transport
GO:0015819 lysine transport
GO:0015822 ornithine transport
GO:0042116 macrophage activation
GO:0043030 regulation of macrophage activation
GO:0050727 regulation of inflammatory response
GO:0055085 transmembrane transport
GO:1902475 L-alpha-amino acid transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031596
View Gene Order
ENSBTAG00000010085
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.448520 Hs.602815
RefSeq NM_001008539 NM_001164771 NM_003046 XM_005273609 XM_005273610 XM_005273611 XM_005273612 XM_006716389
HUGO
OMIM
CCDS CCDS34852 CCDS55203 CCDS6002
HPRD 03524
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca