InnateDB Protein
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IDBP-476663.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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HAVCR1
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Protein Name
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hepatitis A virus cellular receptor 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000427898
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InnateDB Gene
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IDBG-55259 (HAVCR1)
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Protein Structure
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Function |
May play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4 (By similarity). In case of human hepatitis A virus (HHAV) infection, functions as a cell-surface receptor for the virus. May play a role in kidney injury and repair. {ECO:0000250, ECO:0000269PubMed:17471468, ECO:0000269PubMed:9658108}.
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Subcellular Localization |
Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Widely expressed, with highest levels in kidney and testis. Expressed by activated CD4+ T-cells during the development of helper T-cells responses. {ECO:0000269PubMed:9658108}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
2
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR003599
Immunoglobulin subtype
IPR007110
Immunoglobulin-like domain
IPR013106
Immunoglobulin V-set domain
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PFAM |
PF07686
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PRINTS |
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PIRSF |
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SMART |
SM00409
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TIGRFAMs |
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Modification |
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SwissProt |
Q96D42
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PhosphoSite |
PhosphoSite-Q96D42
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TrEMBL |
E5RIF6
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UniProt Splice Variant |
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Entrez Gene |
26762
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UniGene |
Hs.129711
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RefSeq |
NP_001166864
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HUGO |
HGNC:17866
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OMIM |
606518
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CCDS |
CCDS43392
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HPRD |
09404
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IMGT |
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EMBL |
AC026777
AF043724
BC013325
CR457114
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GenPept |
AAC39862
AAH13325
CAG33395
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