InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ARNT

Summary

InnateDB Protein

IDBP-476693.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARNT

Protein Name

aryl hydrocarbon receptor nuclear translocator

Synonyms

bHLHe2; HIF-1-beta; HIF-1beta; HIF1-beta; HIF1B; HIF1BETA; TANGO;

Species

Homo sapiens

Ensembl Protein

ENSP00000423851

InnateDB Gene

IDBG-102199 (ARNT)

Protein Structure

UniProt Annotation

Function

Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 71 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	71 [view]
Protein-Protein	63 [view]
Protein-DNA	6 [view]
Protein-RNA	1 [view]
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0017162	aryl hydrocarbon receptor binding
GO:0035326	enhancer binding
GO:0043565	sequence-specific DNA binding
GO:0046982	protein heterodimerization activity
GO:0046983	protein dimerization activity

Biological Process

GO:0001666	response to hypoxia
GO:0001938	positive regulation of endothelial cell proliferation
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007165	signal transduction
GO:0010575	positive regulation vascular endothelial growth factor production
GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0042789	mRNA transcription from RNA polymerase II promoter
GO:0043619	regulation of transcription from RNA polymerase II promoter in response to oxidative stress
GO:0045648	positive regulation of erythrocyte differentiation
GO:0045821	positive regulation of glycolytic process
GO:0045893	positive regulation of transcription, DNA-templated
GO:0046886	positive regulation of hormone biosynthetic process
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0071456	cellular response to hypoxia

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005667	transcription factor complex

Protein Structure and Domains

PDB ID

InterPro

IPR000014 PAS domain
IPR001067 Nuclear translocator
IPR001610 PAC motif
IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
IPR013655 PAS fold-3
IPR013767 PAS fold

PFAM

PF13188
PF13426
PF00010
PF08447
PF00989

PRINTS

PR00785

PIRSF

SMART

SM00091
SM00086
SM00353

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt