Version 5.4
Homo sapiens Protein: MLF1
Summary
InnateDB Protein IDBP-476704.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MLF1
Protein Name myeloid leukemia factor 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000417777
InnateDB Gene IDBG-63091 (MLF1)
Protein Structure
UniProt Annotation
Function Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus. {ECO:0000269PubMed:15861129}.
Subcellular Localization Cytoplasm. Nucleus. Note=In non- hematopoietic cells, resides primarily in the cytoplasm with some punctate nuclear localization. Shuttles between the cytoplasm and nucleus. In hematopoietic cells, located preferentially in the nucleus. Found in the nucleolus when fused to NPM.
Disease Associations Note=A chromosomal aberration involving MLF1 is a cause of myelodysplastic syndrome (MDS). Translocation t(3;5)(q25.1;q34) with NPM1/NPM.
Tissue Specificity Most abundant in testis, ovary, skeletal muscle, heart, kidney and colon. Low expression in spleen, thymus and peripheral blood leukocytes.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 66 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 66 [view]
Protein-Protein 65 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0019904 protein domain specific binding
Biological Process
GO:0002318 myeloid progenitor cell differentiation
GO:0006351 transcription, DNA-templated
GO:0007050 cell cycle arrest
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR019376 Myeloid leukemia factor
PFAM PF10248
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P58340
PhosphoSite PhosphoSite-P58340
TrEMBL C9K0D3
UniProt Splice Variant
Entrez Gene 4291
UniGene Hs.605551
RefSeq
HUGO HGNC:7125
OMIM 601402
CCDS CCDS56287
HPRD 03239
IMGT
EMBL AC025033 AC106707 AK056948 AK096889 AK297488 AY848700 AY848702 BC007045 CH471052 L49054
GenPept AAA99997 AAH07045 AAX46015 AAX46017 BAB71320 BAC04885 BAG59906 EAW78689 EAW78690

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca