Version 5.4
Homo sapiens Protein: GFRA2
Summary
InnateDB Protein IDBP-476866.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GFRA2
Protein Name GDNF family receptor alpha 2
Synonyms GDNFRB; NRTNR-ALPHA; NTNRA; RETL2; TRNR2;
Species Homo sapiens
Ensembl Protein ENSP00000428518
InnateDB Gene IDBG-9892 (GFRA2)
Protein Structure
UniProt Annotation
Function Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor.
Subcellular Localization Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}.
Disease Associations
Tissue Specificity Isoform 1 is found in both brain and placenta.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0016167 glial cell-derived neurotrophic factor receptor activity
Biological Process
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007399 nervous system development
GO:0031953 negative regulation of protein autophosphorylation
GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0019898 extrinsic component of membrane
GO:0031225 anchored component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR003438 Glial cell line-derived neurotrophic factor receptor
IPR003504 Glial cell line-derived neurotrophic factor receptor alpha 2
IPR016017 GDNF/GAS1
IPR017372 Glial cell line-derived neurotrophic factor receptor, alpha 1/2
PFAM PF02351
PRINTS PR01316
PR01318
PIRSF PIRSF038071
SMART SM00907
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O00451
PhosphoSite PhosphoSite-O00451
TrEMBL E5RJ44
UniProt Splice Variant
Entrez Gene 2675
UniGene Hs.720276
RefSeq NP_001486
HUGO HGNC:4244
OMIM 601956
CCDS CCDS47816
HPRD 11801
IMGT
EMBL AC105186 AC129925 AF002700 AP008236 AY326396 AY941828 BC041688 U93703 U97145
GenPept AAB61922 AAC51647 AAC52036 AAH41688 AAP88378 AAX46325

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca