InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DNM1

Summary

InnateDB Protein

IDBP-476909.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DNM1

Protein Name

dynamin 1

Synonyms

DNM;

Species

Homo sapiens

Ensembl Protein

ENSP00000420045

InnateDB Gene

IDBG-87752 (DNM1)

Protein Structure

UniProt Annotation

Function

Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:15703209}. Cytoplasm, cytoskeleton {ECO:0000269PubMed:15703209}. Note=Microtubule-associated.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 71 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	71 [view]
Protein-Protein	70 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0019901	protein kinase binding
GO:0042802	identical protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006897	endocytosis
GO:0006898	receptor-mediated endocytosis
GO:0007032	endosome organization

Cellular Component

GO:0005874

microtubule

Protein Structure and Domains

PDB ID

InterPro

IPR000375 Dynamin central domain
IPR001401 Dynamin, GTPase domain
IPR001849 Pleckstrin homology domain
IPR003130 Dynamin GTPase effector
IPR022812 Dynamin superfamily
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF01031
PF00350
PF00169
PF02212

PRINTS

PR00195

PIRSF

SMART

SM00053
SM00233
SM00302

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt