InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: DNM1

Summary

InnateDB Gene

IDBG-87752.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DNM1

Gene Name

dynamin 1

Synonyms

DNM

Species

Homo sapiens

Ensembl Gene

ENSG00000106976

Encoded Proteins

IDBP-87754

dynamin 1

IDBP-87756

dynamin 1

IDBP-243290

dynamin 1

IDBP-483297

dynamin 1

IDBP-476909

dynamin 1

IDBP-477092

dynamin 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein possesses unique mechanochemical properties used to tubulate and sever membranes, and is involved in clathrin-mediated endocytosis and other vesicular trafficking processes. Actin and other cytoskeletal proteins act as binding partners for the encoded protein, which can also self-assemble leading to stimulation of GTPase activity. More than sixty highly conserved copies of the 3' region of this gene are found elsewhere in the genome, particularly on chromosomes Y and 15. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein possesses unique mechanochemical properties used to tubulate and sever membranes, and is involved in clathrin-mediated endocytosis and other vesicular trafficking processes. Actin and other cytoskeletal proteins act as binding partners for the encoded protein, which can also self-assemble leading to stimulation of GTPase activity. More than sixty highly conserved copies of the 3\' region of this gene are found elsewhere in the genome, particularly on chromosomes Y and 15. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:128203379-128255248

Strand

Forward strand

Band

q34.11

Transcripts

ENST00000341179	ENSP00000345680
ENST00000372923	ENSP00000362014
ENST00000393594	ENSP00000377219
ENST00000441149
ENST00000475805	ENSP00000419225
ENST00000486160	ENSP00000420045
ENST00000482638	ENSP00000420808
ENST00000463998
ENST00000493925

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 71 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	71 [view]
Protein-Protein	70 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0008022	protein C-terminus binding
GO:0019901	protein kinase binding
GO:0032403	protein complex binding
GO:0042802	identical protein binding
GO:0044822	poly(A) RNA binding
GO:0050998	nitric-oxide synthase binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006897	endocytosis
GO:0006898	receptor-mediated endocytosis
GO:0007032	endosome organization
GO:0031623	receptor internalization