InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IGFBP4

Summary

InnateDB Protein

IDBP-47694.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IGFBP4

Protein Name

insulin-like growth factor binding protein 4

Synonyms

BP-4; HT29-IGFBP; IBP4; IGFBP-4;

Species

Homo sapiens

Ensembl Protein

ENSP00000269593

InnateDB Gene

IDBG-47692 (IGFBP4)

Protein Structure

UniProt Annotation

Function

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005520	insulin-like growth factor binding

Biological Process

GO:0001501	skeletal system development
GO:0001558	regulation of cell growth
GO:0006259	DNA metabolic process
GO:0006954	inflammatory response
GO:0007165	signal transduction
GO:0008283	cell proliferation
GO:0010906	regulation of glucose metabolic process
GO:0040008	regulation of growth
GO:0043410	positive regulation of MAPK cascade
GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway
GO:0044267	cellular protein metabolic process
GO:0044342	type B pancreatic cell proliferation

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space

Protein Structure and Domains

PDB ID

InterPro

IPR000716 Thyroglobulin type-1
IPR000867 Insulin-like growth factor-binding protein, IGFBP
IPR009030 Insulin-like growth factor binding protein, N-terminal
IPR022321 Insulin-like growth factor-binding protein family 1-6, chordata
IPR022327 Insulin-like growth factor-binding protein 4

PFAM

PF00086
PF00219

PRINTS

PR01976
PR01980

PIRSF

SMART

SM00211
SM00121

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt