Version 5.4
Homo sapiens Gene: IGFBP4
Summary
InnateDB Gene IDBG-47692.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IGFBP4
Gene Name insulin-like growth factor binding protein 4
Synonyms BP-4; HT29-IGFBP; IBP4; IGFBP-4
Species Homo sapiens
Ensembl Gene ENSG00000141753
Encoded Proteins
IDBP-47694
insulin-like growth factor binding protein 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:40443461-40457731
Strand Forward strand
Band q21.2
Transcripts
ENST00000269593 ENSP00000269593
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005520 insulin-like growth factor binding
Biological Process
GO:0001501 skeletal system development
GO:0001558 regulation of cell growth
GO:0006259 DNA metabolic process
GO:0006954 inflammatory response
GO:0007165 signal transduction
GO:0008283 cell proliferation
GO:0010906 regulation of glucose metabolic process
GO:0040008 regulation of growth
GO:0043410 positive regulation of MAPK cascade
GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway
GO:0044267 cellular protein metabolic process
GO:0044342 type B pancreatic cell proliferation
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000017493
View Gene Order
ENSBTAG00000008611
Not yet available
Pathways
NETPATH
REACTOME
REACT_15428
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) pathway
REACT_17015
Metabolism of proteins pathway
KEGG
INOH
INOH website
IGF1 signaling pathway pathway
PID NCI
wnt_signaling_pathway
Wnt signaling network
Cross-References
SwissProt P22692
TrEMBL A0A024R1U8 B4E351
UniProt Splice Variant
Entrez Gene 3487
UniGene Hs.462998
RefSeq NM_001552
HUGO HGNC:5473
OMIM 146733
CCDS CCDS11367
HPRD
IMGT
EMBL AC018629 AK304572 AY442346 BC016041 BT019891 BT019892 CH471152 M38177 M62403 U20982 Y12508
GenPept AAA62670 AAB06189 AAH16041 AAR05443 AAV38694 AAV38695 BAG65363 CAA73110 EAW60664 EAW60665
RNA Seq Atlas 3487

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca