Homo sapiens Protein: SIGLEC1 | |||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Summary | |||||||||||||||
InnateDB Protein | IDBP-47697.6 | ||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||
Gene Symbol | SIGLEC1 | ||||||||||||||
Protein Name | sialic acid binding Ig-like lectin 1, sialoadhesin | ||||||||||||||
Synonyms | CD169; dJ1009E24.1; SIGLEC-1; SN; | ||||||||||||||
Species | Homo sapiens | ||||||||||||||
Ensembl Protein | ENSP00000341141 | ||||||||||||||
InnateDB Gene | IDBG-47695 (SIGLEC1) | ||||||||||||||
Protein Structure | |||||||||||||||
UniProt Annotation | |||||||||||||||
Function | Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Preferentially binds to alpha-2,3-linked sialic acid (By similarity). Binds to SPN/CD43 on T-cells (By similarity). May play a role in hemopoiesis. {ECO:0000250}. | ||||||||||||||
Subcellular Localization | Isoform 1: Cell membrane; Single-pass type I membrane protein.Isoform 2: Secreted. | ||||||||||||||
Disease Associations | |||||||||||||||
Tissue Specificity | Expressed by macrophages in various tissues. High levels are found in spleen, lymph node, perivascular macrophages in brain and lower levels in bone marrow, liver Kupffer cells and lamina propria of colon and lung. Also expressed by inflammatory macrophages in rheumatoid arthritis. | ||||||||||||||
Comments | |||||||||||||||
Interactions | |||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
|
||||||||||||||
Gene Ontology | |||||||||||||||
Molecular Function |
|
||||||||||||||
Biological Process |
|
||||||||||||||
Cellular Component |
|
||||||||||||||
Protein Structure and Domains | |||||||||||||||
PDB ID | |||||||||||||||
InterPro |
IPR003598
Immunoglobulin subtype 2 IPR003599 Immunoglobulin subtype IPR007110 Immunoglobulin-like domain IPR013098 Immunoglobulin I-set IPR013106 Immunoglobulin V-set domain IPR013151 Immunoglobulin IPR013162 CD80-like, immunoglobulin C2-set |
||||||||||||||
PFAM |
PF07679
PF07686 PF00047 PF08205 |
||||||||||||||
PRINTS | |||||||||||||||
PIRSF | |||||||||||||||
SMART |
SM00408
SM00409 |
||||||||||||||
TIGRFAMs | |||||||||||||||
Post-translational Modifications | |||||||||||||||
Modification | |||||||||||||||
Cross-References | |||||||||||||||
SwissProt | Q9BZZ2 | ||||||||||||||
PhosphoSite | PhosphoSite-Q9BZZ2 | ||||||||||||||
TrEMBL | |||||||||||||||
UniProt Splice Variant | |||||||||||||||
Entrez Gene | 6614 | ||||||||||||||
UniGene | Hs.619237 | ||||||||||||||
RefSeq | NP_075556 | ||||||||||||||
HUGO | HGNC:11127 | ||||||||||||||
OMIM | 600751 | ||||||||||||||
CCDS | CCDS13060 | ||||||||||||||
HPRD | 02854 | ||||||||||||||
IMGT | |||||||||||||||
EMBL | AF230073 AK024459 AK024462 AK024479 AK057560 AL109804 | ||||||||||||||
GenPept | AAK00757 BAB15749 BAB15752 BAB15769 BAB71527 CAC17542 CAC17543 | ||||||||||||||