Version 5.4
Homo sapiens Gene: SIGLEC1
Summary
InnateDB Gene IDBG-47695.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SIGLEC1
Gene Name sialic acid binding Ig-like lectin 1, sialoadhesin
Synonyms CD169; dJ1009E24.1; SIGLEC-1; SN
Species Homo sapiens
Ensembl Gene ENSG00000088827
Encoded Proteins
IDBP-47697
sialic acid binding Ig-like lectin 1, sialoadhesin
IDBP-364194
sialic acid binding Ig-like lectin 1, sialoadhesin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21208791
SIGLEC1 is a member of the SIGLEC protein family that recognize sialoside-based patterns and plays a role in the attenuation of innate immunity to avoid autoimmune destruction.
InnateDB Annotation from Orthologs
Summary
PMID 21208791
[Mus musculus] Siglec1 is a member of the SIGLEC protein family that recognize sialoside-based patterns and plays a role in the attenuation of innate immunity to avoid autoimmune destruction.
Entrez Gene
Summary This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. Alternative splicing produces a transcript variant encoding an isoform that is soluble rather than membrane-bound; however, the full-length nature of this variant has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:3686970-3707128
Strand Reverse strand
Band p13
Transcripts
ENST00000344754 ENSP00000341141
ENST00000419548 ENSP00000395778
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0030246 carbohydrate binding
Biological Process
GO:0006897 endocytosis
GO:0006954 inflammatory response
GO:0007160 cell-matrix adhesion
GO:0016337 single organismal cell-cell adhesion
GO:0045087 innate immune response (InnateDB)
GO:0070234 positive regulation of T cell apoptotic process
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027322
View Gene Order
ENSBTAG00000013167
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04514
Cell adhesion molecules (CAMs) pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.31869 Hs.619237
RefSeq NM_023068 XM_006723610 XM_006723613
HUGO
OMIM
CCDS CCDS13060
HPRD 02854
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca