InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DAPP1

Summary

InnateDB Protein

IDBP-477070.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DAPP1

Protein Name

dual adaptor of phosphotyrosine and 3-phosphoinositides

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000423602

InnateDB Gene

IDBG-31523 (DAPP1)

Protein Structure

UniProt Annotation

Function

May act as a B-cell-associated adapter that regulates B- cell antigen receptor (BCR)-signaling downstream of PI3K. {ECO:0000269PubMed:10770799}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:10770799}. Membrane {ECO:0000269PubMed:10770799}; Peripheral membrane protein {ECO:0000269PubMed:10770799}. Note=Membrane-associated after cell stimulation leading to its translocation.

Disease Associations

Tissue Specificity

Highly expressed in placenta and lung, followed by brain, heart, kidney, liver, pancreas and skeletal muscle. Expressed by B-lymphocytes, but not T-lymphocytes or nonhematopoietic cells. {ECO:0000269PubMed:10432293}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005543	phospholipid binding
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding
GO:0043325	phosphatidylinositol-3,4-bisphosphate binding