InnateDB Protein
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IDBP-477149.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SYP
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Protein Name
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synaptophysin
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Synonyms
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MRX96; MRXSYP;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000418169
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InnateDB Gene
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IDBG-65720 (SYP)
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Protein Structure
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Function |
Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein. Cell junction, synapse, synaptosome.
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Disease Associations |
Mental retardation, X-linked, SYP-related (MRXSYP) [MIM:300802]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. {ECO:0000269PubMed:19377476}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
Characteristic of a type of small (30-80 nm) neurosecretory vesicles, including presynaptic vesicles, but also vesicles of various neuroendocrine cells of both neuronal and epithelial phenotype.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated |
Total |
9
[view]
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Protein-Protein |
9
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
10 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001285
Synaptophysin/synaptoporin
IPR008253
Marvel domain
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PFAM |
PF01284
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PRINTS |
PR00220
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P08247
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PhosphoSite |
PhosphoSite-P08247
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TrEMBL |
B7Z359
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UniProt Splice Variant |
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Entrez Gene |
6855
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UniGene |
Hs.632804
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RefSeq |
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HUGO |
HGNC:11506
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OMIM |
313475
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CCDS |
CCDS14321
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HPRD |
02435
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IMGT |
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EMBL |
AF196779
AK295524
AK313030
AK315953
BC064550
CH471224
U93305
X06389
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GenPept |
AAB92358
AAH64550
BAG35863
BAH12095
BAH14324
CAA29686
EAW50685
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