InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SYP

Summary

InnateDB Gene

IDBG-65720.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SYP

Gene Name

synaptophysin

Synonyms

MRX96; MRXSYP

Species

Homo sapiens

Ensembl Gene

ENSG00000102003

Encoded Proteins

IDBP-65722

synaptophysin

IDBP-65724

synaptophysin

IDBP-483364

synaptophysin

IDBP-477149

synaptophysin

IDBP-478558

synaptophysin

IDBP-482372

synaptophysin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 7559603

SYP is a protein tyrosine phosphatase that associates with IL6ST and JAK2 in IL-11 signal transduction pathway.

Entrez Gene

Summary

This gene encodes an integral membrane protein of small synaptic vesicles in brain and endocrine cells. The protein also binds cholesterol and is thought to direct targeting of vesicle-associated membrane protein 2 (synaptobrevin) to intracellular compartments. Mutations in this gene are associated with X-linked mental retardation (XLMR). [provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:49187804-49200259

Strand

Reverse strand

Band

p11.23

Transcripts

ENST00000376303	ENSP00000365480
ENST00000263233	ENSP00000263233
ENST00000472598	ENSP00000418387
ENST00000479808	ENSP00000418169
ENST00000469389	ENSP00000418987
ENST00000466635	ENSP00000420774
ENST00000494396
ENST00000472737

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005515	protein binding
GO:0015485	cholesterol binding
GO:0017075	syntaxin-1 binding
GO:0019904	protein domain specific binding
GO:0032403	protein complex binding
GO:0042169	SH2 domain binding
GO:0042802	identical protein binding

Biological Process

GO:0006810	transport
GO:0006897	endocytosis
GO:0016188	synaptic vesicle maturation
GO:0045087	innate immune response (InnateDB)
GO:0048168	regulation of neuronal synaptic plasticity
GO:0048169	regulation of long-term neuronal synaptic plasticity
GO:0048172	regulation of short-term neuronal synaptic plasticity
GO:0048499	synaptic vesicle membrane organization
GO:0071310	cellular response to organic substance
GO:2000474	regulation of opioid receptor signaling pathway

Cellular Component

GO:0008021	synaptic vesicle
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0030285	integral component of synaptic vesicle membrane
GO:0030672	synaptic vesicle membrane
GO:0042734	presynaptic membrane
GO:0043005	neuron projection
GO:0043229	intracellular organelle
GO:0043234	protein complex
GO:0044306	neuron projection terminus
GO:0045202	synapse
GO:0048786	presynaptic active zone
GO:0060076	excitatory synapse

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000031144

View Gene Order

ENSBTAG00000016096

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.632804

RefSeq

NM_003179

HUGO

OMIM

CCDS

CCDS14321

HPRD

02435

IMGT

EMBL

GenPept

RNA Seq Atlas