InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: COL13A1

Summary

InnateDB Protein

IDBP-477179.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

COL13A1

Protein Name

collagen, type XIII, alpha 1

Synonyms

COLXIIIA1;

Species

Homo sapiens

Ensembl Protein

ENSP00000428342

InnateDB Gene

IDBG-77110 (COL13A1)

Protein Structure

UniProt Annotation

Function

Involved in cell-matrix and cell-cell adhesion interactions that are required for normal development. May participate in the linkage between muscle fiber and basement membrane. May play a role in endochondral ossification of bone and branching morphogenesis of lung. Binds heparin. {ECO:0000250UniProtKB:Q9R1N9, ECO:0000269PubMed:10865988, ECO:0000269PubMed:11956183}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:11013208}; Single-pass type II membrane protein {ECO:0000250UniProtKB:Q9R1N9, ECO:0000269PubMed:11013208}.

Disease Associations

Tissue Specificity

Widely expressed in both fetal and adult ocular tissues (at protein level). In the eye, expression is accentuated in the ciliary muscle, optic nerve and the neural retina. In early placenta, localized to fibroblastoid stromal cells of the placental villi, to endothelial cells of developing capillaries and to cells of the cytotrophoblastic columns. Also detected in large decidual cells of the decidual membrane and to stromal cells of the gestational endometrium, but not in the epithelial cells in the endometrial glands. {ECO:0000269PubMed:10865988, ECO:0000269PubMed:8246446}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008201	heparin binding

Biological Process

GO:0001763	morphogenesis of a branching structure
GO:0001958	endochondral ossification
GO:0007160	cell-matrix adhesion
GO:0016337	single organismal cell-cell adhesion
GO:0022617	extracellular matrix disassembly
GO:0030154	cell differentiation
GO:0030198	extracellular matrix organization
GO:0030574	collagen catabolic process