InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC26A7

Summary

InnateDB Protein

IDBP-477268.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC26A7

Protein Name

solute carrier family 26, member 7

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000428849

InnateDB Gene

IDBG-28311 (SLC26A7)

Protein Structure

UniProt Annotation

Function

Acts as a sodium-independent DIDS-sensitive anion exchanger mediating bicarbonate, chloride, sulfate and oxalate transport. May play a role in the maintenance of the electrolyte and acid-base homeostasis in the kidney, by acting as a distal excretory segment-specific anion exchanger. Plays a major role in gastric acid secretion. {ECO:0000250UniProtKB:Q8R2Z3, ECO:0000269PubMed:11834742, ECO:0000269PubMed:12736153}.

Subcellular Localization

Recycling endosome membrane {ECO:0000269PubMed:16524946}; Multi-pass membrane protein {ECO:0000269PubMed:16524946}. Note=Expressed in the cytoplasm in recycling endosomes of medullary collecting duct cells and in acid-secreting gastric parietal cells. Targeted to the basolateral membrane in hypertonicity and potassium depletion. {ECO:0000269PubMed:16524946}.

Disease Associations

Tissue Specificity

Expressed in tonsillar high endothelial venule endothelial cells (HEVEC), placenta and in testis, expressed in a subgroup of basal cells in the epididymal ducts. {ECO:0000269PubMed:11829495, ECO:0000269PubMed:11834742, ECO:0000269PubMed:15956810, ECO:0000269PubMed:17504921}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005254	chloride channel activity
GO:0015106	bicarbonate transmembrane transporter activity
GO:0015116	sulfate transmembrane transporter activity
GO:0015301	anion:anion antiporter activity
GO:0019531	oxalate transmembrane transporter activity

Biological Process

GO:0006811	ion transport
GO:0006820	anion transport
GO:0006821	chloride transport
GO:0008272	sulfate transport
GO:0015701	bicarbonate transport
GO:0019532	oxalate transport
GO:0055085	transmembrane transport
GO:1902358	sulfate transmembrane transport
GO:1902476	chloride transmembrane transport

Cellular Component

GO:0005737	cytoplasm
GO:0005768	endosome
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0055038	recycling endosome membrane