InnateDB Protein
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IDBP-477368.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ZC3HAV1
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Protein Name
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zinc finger CCCH-type, antiviral 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000419855
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InnateDB Gene
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IDBG-43487 (ZC3HAV1)
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Protein Structure
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Function |
Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)- specific ribonuclease PARN to remove the poly(A) tail, and the 3'- 5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of DDX58/RIG-I signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs). {ECO:0000269PubMed:18225958, ECO:0000269PubMed:21102435, ECO:0000269PubMed:21876179, ECO:0000269PubMed:22720057}.
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Subcellular Localization |
Isoform 1: Cytoplasm. Nucleus. Note=Localizes in the cytoplasm at steady state, but shuttles between nucleus and cytoplasm in a XPO1-dependent manner. {ECO:0000250}.Isoform 2: Cytoplasm.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 47 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
47
[view]
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Protein-Protein |
43
[view]
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Protein-DNA |
3
[view]
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0008152
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metabolic process
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GO:0009615
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response to virus
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GO:0032727
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positive regulation of interferon-alpha production
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GO:0032728
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positive regulation of interferon-beta production
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GO:0043123
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positive regulation of I-kappaB kinase/NF-kappaB signaling
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GO:0045071
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negative regulation of viral genome replication
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GO:0045087
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innate immune response (InnateDB)
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GO:0051607
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defense response to virus
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GO:0061014
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positive regulation of mRNA catabolic process
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GO:1900246
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positive regulation of RIG-I signaling pathway
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Cellular Component |
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PDB ID |
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InterPro |
IPR004170
WWE domain
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PFAM |
PF02825
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q7Z2W4
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PhosphoSite |
PhosphoSite-Q7Z2W4
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
56829
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UniGene |
Hs.609466
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RefSeq |
NP_078901
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HUGO |
HGNC:23721
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OMIM |
607312
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CCDS |
CCDS55171
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HPRD |
09534
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IMGT |
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EMBL |
AF138863
AK023350
AK055851
BC025308
BC027462
BC033105
BC040956
BX571742
CH236950
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GenPept |
AAF61195
AAH25308
AAH27462
AAH33105
AAH40956
BAB14537
BAB71028
CAE11868
EAL24040
EAL24041
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