InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ZC3HAV1

Summary

InnateDB Gene

IDBG-43487.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZC3HAV1

Gene Name

zinc finger CCCH-type, antiviral 1

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000105939

Encoded Proteins

IDBP-43491

zinc finger CCCH-type, antiviral 1

IDBP-479353

zinc finger CCCH-type, antiviral 1

IDBP-477368

zinc finger CCCH-type, antiviral 1

IDBP-481842

zinc finger CCCH-type, antiviral 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21102435

ZC3HAV1 isoform ZAPS is selectively induced by 5'-triphosphate-modified RNA and functions as a potent stimulator of interferon responses via the RIG-I signalling pathway.

InnateDB Annotation from Orthologs

Summary

PMID 21102435

[Mus musculus] Zc3hav1 isoform ZAPS is selectively induced by 5'-triphosphate-modified RNA and functions as a potent stimulator of interferon responses via the RIG-I signalling pathway.

Entrez Gene

Summary

This gene encodes a CCCH-type zinc finger protein that is thought to prevent infection by retroviruses. Studies of the rat homolog indicate that the protein may primarily function to inhibit viral gene expression and induce an innate immunity to viral infection. Alternative splicing occurs at this locus and two variants, each encoding distinct isoforms, are described. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:139043520-139109719

Strand

Reverse strand

Band

q34

Transcripts

ENST00000242351	ENSP00000242351
ENST00000464606	ENSP00000418385
ENST00000471652	ENSP00000419855
ENST00000460845	ENSP00000420107

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 47 experimentally validated interaction(s) in this database.

Experimentally validated
Total	47 [view]
Protein-Protein	43 [view]
Protein-DNA	3 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003950	NAD+ ADP-ribosyltransferase activity
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding

Biological Process

GO:0008152	metabolic process
GO:0009615	response to virus
GO:0032481	positive regulation of type I interferon production
GO:0032727	positive regulation of interferon-alpha production
GO:0032728	positive regulation of interferon-beta production
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045071	negative regulation of viral genome replication
GO:0045087	innate immune response (InnateDB)
GO:0051607	defense response to virus
GO:0061014	positive regulation of mRNA catabolic process
GO:0071360	cellular response to exogenous dsRNA
GO:1900246	positive regulation of RIG-I signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000029826

View Gene Order

ENSBTAG00000021617

Not yet available

Pathways

NETPATH

NetPath_24

TSLP pathway

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.133512 Hs.607799 Hs.609466

RefSeq

NM_020119 NM_024625

HUGO

OMIM

CCDS

CCDS55171 CCDS5851

HPRD

09534

IMGT

EMBL

GenPept

RNA Seq Atlas