InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MYSM1

Summary

InnateDB Protein

IDBP-477401.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MYSM1

Protein Name

Myb-like, SWIRM and MPN domains 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000418734

InnateDB Gene

IDBG-99218 (MYSM1)

Protein Structure

UniProt Annotation

Function

Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation. {ECO:0000269PubMed:17707232}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00624, ECO:0000269PubMed:17707232}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	18 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003713	transcription coactivator activity
GO:0004221	ubiquitin thiolesterase activity
GO:0004843	ubiquitin-specific protease activity
GO:0005515	protein binding
GO:0008237	metallopeptidase activity
GO:0032403	protein complex binding
GO:0042393	histone binding
GO:0046872	metal ion binding

Biological Process

GO:0006338	chromatin remodeling
GO:0006351	transcription, DNA-templated
GO:0006508	proteolysis
GO:0035522	monoubiquitinated histone H2A deubiquitination
GO:0045944	positive regulation of transcription from RNA polymerase II promoter