InnateDB Protein
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IDBP-477408.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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NOBOX
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Protein Name
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NOBOX oogenesis homeobox
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000419565
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InnateDB Gene
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IDBG-46656 (NOBOX)
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Protein Structure
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Function |
Transcription factor which may play a role in oogenesis. Binds preferentially to the DNA sequences 5'-TAATTG-3', 5'-TAGTTG- 3' and 5'-TAATTA-3' (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000255PROSITE- ProRule:PRU00108}.
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Disease Associations |
Premature ovarian failure 5 (POF5) [MIM:611548]: An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol. {ECO:0000269PubMed:17701902, ECO:0000269PubMed:21837770}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
Expressed in ovaries, testes and pancreas. Expressed within all stages of the adult female germline, from primordial follicles through to MII oocytes. {ECO:0000269PubMed:16597639}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001356
Homeobox domain
IPR009057
Homeodomain-like
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PFAM |
PF00046
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PRINTS |
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PIRSF |
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SMART |
SM00389
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TIGRFAMs |
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Modification |
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SwissProt |
O60393
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PhosphoSite |
PhosphoSite-O60393
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
135935
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UniGene |
Hs.558628
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RefSeq |
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HUGO |
HGNC:22448
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OMIM |
610934
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AC004534
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GenPept |
AAC12957
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