Version 5.4
Homo sapiens Protein: DENND2A
Summary
InnateDB Protein IDBP-477794.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DENND2A
Protein Name DENN/MADD domain containing 2A
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000419654
InnateDB Gene IDBG-44191 (DENND2A)
Protein Structure
UniProt Annotation
Function Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP- bound form. May play a role in late endosomes back to trans-Golgi network/TGN transport. {ECO:0000269PubMed:20937701}.
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000269PubMed:20937701}. Note=Associated with actin filaments.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0017112 Rab guanyl-nucleotide exchange factor activity
Biological Process
GO:0015031 protein transport
GO:0032851 positive regulation of Rab GTPase activity
GO:0042147 retrograde transport, endosome to Golgi
Cellular Component
GO:0005737 cytoplasm
GO:0015629 actin cytoskeleton
Protein Structure and Domains
PDB ID
InterPro IPR001194 DENN domain
IPR005112 dDENN domain
IPR005113 uDENN domain
PFAM PF02141
PF03455
PF03456
PRINTS
PIRSF
SMART SM00799
SM00801
SM00800
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9ULE3
PhosphoSite PhosphoSite-Q9ULE3
TrEMBL C9JD15
UniProt Splice Variant
Entrez Gene 27147
UniGene Hs.6385
RefSeq XP_005250033
HUGO HGNC:22212
OMIM
CCDS CCDS43659
HPRD 17210
IMGT
EMBL AB033103 AC006452 AC069335 BC049193 BC115004
GenPept AAH49193 AAI15005 BAA86591

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca