Version 5.4
Homo sapiens Protein: C6orf170
Summary
InnateDB Protein IDBP-477889.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol C6orf170
Protein Name chromosome 6 open reading frame 170
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000428839
InnateDB Gene IDBG-95977 (C6orf170)
Protein Structure
UniProt Annotation
Function Required for high-level Shh responses in the developing neural tube. Together with CDK20, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to Shh signaling (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Cell projection, cilium {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005097 Rab GTPase activator activity
Biological Process
GO:0007275 multicellular organismal development
GO:0032851 positive regulation of Rab GTPase activity
Cellular Component
GO:0005737 cytoplasm
GO:0005929 cilium
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96NH3
PhosphoSite PhosphoSite-Q96NH3
TrEMBL
UniProt Splice Variant
Entrez Gene 221322
UniGene Hs.738569
RefSeq
HUGO HGNC:21485
OMIM 615867
CCDS
HPRD 12867
IMGT
EMBL AK055461 AK091554 AK125385 AK131446 AL035593 AL139098 AL365508 AL589910 AL590225
GenPept BAB70925 BAC03694 BAC86152 BAD18591 CAI13226 CAI13628 CAI16051 CAI20000 CAI20139 CAM16339 CAM17813 CAM22453 CAM28224

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca